None listed
Conditions
Interventions
Drug : The experimental protocols were explained verbally to each subject, and written informed consent was obtained from each. Prior to the actual experimental day, each subject was familiarized with
Aspect Medical Systems, Inc., Norwood, MA, USA) was utilized to monitor consciousness.
The middle cerebral artery was insonated by placing a 2-MHz Doppler probe (Companion III, Viasys Healthcare, Madi
Hokanson, Inc., Bellevue, WA), which inflates a large cuff to 50 mmHg in less than 0.3 s and deflates it in less than 0.2 s. After 2 min of inflation, the cuffs were deflated to produce at least a 10-
Sponsors
Asan Medical Center
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: healthy male volunteer betwenn 19 and 60 years
Exclusion criteria
Exclusion criteria: All subjects were free of any known cardiovascular or cerebrovascular diseases and were not taking any medications.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in blood pressure and signal analysis;Changes in blood pressure and cerebral blood flow in middle cerebral artery and signal analysis | — |
Secondary
| Measure | Time frame |
|---|---|
| Response of cardiovascular autonomic nervous system by melatonin administration;Response of dynamic cerebral autoregulation by melatonin administration | — |
Countries
Korea, Republic of
Contacts
Public ContactJi-Yeon Bang
Asan Medical Center
Outcome results
None listed