Comparison of Ramosetron, Ondansetron and Palonosetron for the Prevention of Postoperative Nausea and Vomiting in Patients Undergoing Craniotomy

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0000122

Enrollment

156

Registered

2011-06-08

Start date

2011-05-10

Completion date

Unknown

Last updated

2019-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : Patients were randomized to one of three active treatment groups. A single IV dose of palonosetron (0.075 mg), ondansetron 8 mg, or ramosetron 0.3 mg with an adequate volume of saline solution

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. undergoing craniotomy surgery 2. age older than 21 3. written informed consent

Exclusion criteria

Exclusion criteria: 1. do not have written informed consent 2. emergency operation 3. do not understand nause, vomiting scoring 4. pregnant women 5. hypersensitivity to drugs 6. intubated state in ICU 7. bleeding or reoperation 8. body weight less than 40 kg 9. patient who has antiemetic effect medication 24 hours before surgery

Design outcomes

Primary

Measure	Time frame
Incidence of PONV	—

Secondary

Measure	Time frame
Nausea VRS (verbal rating scale) score;rescue therapy	—

Countries

Korea, Republic of

Contacts

Public ContactJun Gol Song

Asan Medical Center

Outcome results