The effect of peri-procedural short-term steroid therapy for preventing atrial arrhythmia in blanking period after catheter ablation of atrial fibrillation

The Effect of Peri-procedural short-term Steroids therapy for preventing atrial arrhythmia in blanking period after Catheter Ablation of Atrial fibrillation

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CRIS

Registry ID

KCT0000107

Enrollment

100

Registered

2011-04-14

Start date

2010-07-08

Completion date

Unknown

Last updated

2019-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : Methylprednisolone 0.5mg/kg IV bolus injection in pre albation period Methylprednisolone 12mg qd during post ablation day 2~5

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Over 18 years old, first catheter ablation of atrial fibrillation 2) Transthoracic echocardiographically LA dimension <55mm 3) Paroxysmal atrial fibrillation and persistent atrial fibrillation 4) A patient who agreed the writtend informed consent

Exclusion criteria

Exclusion criteria: 1) A patient who rejected the informed consent 2) currently steroid treatment 3) active inflammation 4) active gastric and duodenal ulcer 5) active viral hepatitis or elevated liver enzyme 6) concurrent life threathening disease; end stage renal disease, end stage heart failure 7) documented osteroporosis and osteroporotic fracture 8) prosthetic valve replacement or LA dimension > 55mm

Design outcomes

Primary

Measure	Time frame
Atrial tachycardiarrhythmia over 30 seconed (atrial tachycardia, atrial flutter, and atrial fibrillation) on EKG (Holter, event recorder, 12 lead ECG, hand held device)	—

Secondary

Measure	Time frame
Clinical events(admission, ER visit, antiarrhythmic drug restart, DC cardioversion)	—

Countries

Korea, Republic of

Contacts

Public ContactYoo Ri Kim

Asan Medical Center

Outcome results