None listed
Conditions
Interventions
Drug, Medical Device, Procedure/Surgery : 1) Day 0: evaluation of leptomeningeal carcinomatosis (LMC) related symptoms
2) Lumbar drainage is installed 2 hours before VLP to confirm constant CSF flow.
IV fluids, tube feedings, or TPN indicated =24 hrs
Confusion Confusion or delirium interfering with ADL Disorientation to
person
Seizure Sz's in which consciousness is altered
poorly controlled sz, with breakthrough generalized sz's despite medical intervention One brief
generalized Sz? grade 2
*Encephalopathy Signs or symptoms interfering with ADL
hospitalization indicated Altered mentality
*Symptoms of MTX-related encephalopathy are delirium, agitation, incoherent speech, tremor, nystagmus, seizure, etc
Sponsors
National Cancer Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) diagnosis of leptomeningeal carcinomatosis (LMC) by either CSF cytology or definite MR findings 2) at least one symptom of LMC; headache or increased intracranial pressure (> 15cm H2o), hydrocephalus, cranial neuropathy or cauda equine symptoms 3) patient agree to the experimental protocol
Exclusion criteria
Exclusion criteria: 1) CSF pathway block on wholspine MRI or RI cisternography, 2) Brain space occupying lesion, which could possibly cause herniation 3) Hemorrhagic brain metastasis 4) More than grade 3 leucopenia (ANC < 1,000) or thrombocytopenia (< 50K) 5) Altered mentality as severe as verbal communication is not possible 6) Active systemic cancer progression, at which expected survival is less than 2 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cauda Equina symptoms;intracranial pressure ;altered mentality;Cranial neuropathy | — |
Secondary
| Measure | Time frame |
|---|---|
| CSF MTX level;serum MTX level;CSF cytology;Carcinoembryonic antige (CEA) | — |
Countries
Korea, Republic of
Contacts
Public ContactHo-shin Gwak
National Cancer Center
Outcome results
None listed