None listed
Conditions
Interventions
Drug, Medical Device : 1. Keigai-rengyo-to extract: We purchase Keigai-rengyo-to extract from the Han Kook Sin Yak Pharm. Co. Ltd which equipped Korean good manufacturing practice (KGMP) facility. Thi
Sponsors
KyungHee University Medical Center
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1. Participants are between 13 to 35 years old in male 2. They have more than 10 papules and less than 20 nodules on the face ( Korean Acne Grading System grade 2 to 4) 3. They have had acne for more than 3 months (chronic stage).
Exclusion criteria
Exclusion criteria: Participants will be excluded for the following reasons: 1) they have used western treatment such as retinoids, antibodies, chemical peeling, intense pulsed light or laser treatment, or traditional Chinese medical treatment such like herbal medicine or acupuncture within 1 month before entry; 2) on screening via blood test, they do not meet the normal range (hemoglobin=10g/dl, platelet=100000/mm3, AST, ALT=40 IU/L, Bun>30mg/dl and Creatinine>1.2mg/dl); 3) they have papules or nodules mainly located on the chest or back; 4) they have keloid acne, corticosteroid acne, or other infectious skin disease; 5) they have internal disease that required treatment without delay; 6) they are unable to comply with the study guidelines.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the percentage change of acne inflammatory lesions between baseline and end of trial | — |
Secondary
| Measure | Time frame |
|---|---|
| the percentage change of acne non-inflammatory lesions between baseline and end of trial;the count of inflammatory lesions;the count of non-inflammatory lesions;Skindex-29 (quality of life in patients with skin disease);VAS (Visual Analogue Scale; score 0 (no symptom) to 100 (sever symptom);IGA(investigator Global Assessment; from score 1 (very good) to 5 (very poor) | — |
Countries
Korea, Republic of
Contacts
Public ContactKyu Seok Kim
Kyung Hee University
Outcome results
None listed