None listed
Conditions
Interventions
Drug : Patients assigned to VR will receive vancomycin 1 g iv plus RFP 300 mg po every 12 h, and patients assigned to V receive vancomycin 1 g iv every 12 h.
Sponsors
Asan Medical Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Adult patients = 18 years of age will be screened daily for clinical signs and symptoms consistent with nosocomial pneumonia, i.e., one developed 48 h or later after admission.: had to meet two criteria (a,b) a. A patient had to have a chest radiograph consistent with the diagnosis of pneumonia (new or persistent radiographic infiltrates(new or progressive infiltrates, consolidation, with/without pleural effusion b. Modified CPIS (clinical pulmonary infection score) = 4
Exclusion criteria
Exclusion criteria: a.presence ofmeningitis, endocarditis, or osteomyelitis b.bone marrow tranplantation or organ transplantation c.vancomycin treatment for = 48 h for any reason in the preceding week; d.elevated liver enzymes (= 3 times the upper limits of normal) or total bilirubin = 3.0 mg/dL e.severe neutropenia (< 1000 cells /mm3) or human immunodeficiency virus infection f.chemotherapy or persistent immunosuppression is needed g.a pathogen resistant to RFP or vancomycin
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical cure rate | — |
Secondary
| Measure | Time frame |
|---|---|
| microbiologic eradication;Mortality rate | — |
Countries
Korea, Republic of
Contacts
Public ContactYoung Ju Jung
Asan Medical Center
Outcome results
None listed