None listed
Conditions
Interventions
Drug : Palonosetron: 0.075 mg intravenous injection 30 minutes ago completion of surgery
Sponsors
The Catholic University of Korea, Seoul St. Mary's Hospital
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Patients undergoing thyroid surgery, with a risk of PONV exceeding 60% are selected according to the expected risk for PONV using the simplified risk score of Apfel et al. The 4 risk factors considered in this score are female gender, nonsmoking, the use of postoperative opioids, and prior history of motion sickness or PONV; the presence of 0, 1, 2, 3, or 4 of these risk factors correspond to approximately 10, 20, 40, 60, and 80% risk for PONV, respectively. Basic inclusion criteria are nonsmoking, female patients, and use of postoperative opioid.
Exclusion criteria
Exclusion criteria: Patients who have severe impairment of bowel motility, insulin-dependent diabetes mellitus, pregnancy or breastfeeding, administration of antiemetic medication within 24 hours before surgery, systemic treatment with steroids within 24 hours before surgery or during 48 hours after surgery, obesity (body mass index >=35 kg/m2),impaired renal and/or hepatic function, or require radical neck dissection
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| incidence and severity of postoperative nausea and vomiting | — |
Secondary
| Measure | Time frame |
|---|---|
| requirement for anti-emetic rescue medication ;pain degree (Visual analogue scale) and requirement for analgesic rescue medication;total dose of fentanyl used in intravenous patient-controlled analgesia;Incidence of side effects (Headache, dizziness, and drowsiness) | — |
Countries
Korea, Republic of
Contacts
Public ContactYoung Eun Moon
The Catholic University of Korea, Seoul St. Mary's Hospital
Outcome results
None listed