The prospective trial to validate the effect of continuous infusion of low-dose esmolol on the requirement of inhalation anesthetics and opioid during surgery

The effect of continuous infusion of low-dose esmolol on the requirement of inhalation anesthetics and opioid during surgery

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0000007

Enrollment

Registered

2010-06-28

Start date

2009-12-21

Completion date

Unknown

Last updated

2019-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : esmolol: a 0.5 mg/kg loading dose of followed by an infusion of 30 &micro

g/kg/min during surgery

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: ???????(ASA) ?? 1 ?? 2? ????? ???? ? ???? ??? ??? ?? ??

Exclusion criteria

Exclusion criteria: patients with cardiovascular diseases such as hypertension, arrhythmia, or myocardial ischemia; unstable hemodynamics due to haemorrhage, hypovolemia, or loss of body fluids; asthma or chronic obstructive pulmonary diseases; allergies to the study drug; or body mass index below 16 or over 30 kg/m2, as well as patients requiring opioids for pain diseases and those who refused to participate

Design outcomes

Primary

Measure	Time frame
average effect-site concentration of remifentanil;ratio of average to adequate effect-site concentration of remifentanil;frequency of increase and decrease in the effect-site concentration of remifentanil per hour	—

Secondary

Measure	Time frame
time to awakening & orientation;level of postoperative pain;total dose of fentanyl;length of stay in the PACU	—

Countries

Korea, Republic of

Contacts

Public ContactWon-jung Hwang

The Catholic University of Korea, Seoul St. Mary's Hospital

Outcome results