Liver disease indicated for liver transplantation
Conditions
Interventions
Use of machine perfusion during the preservation of the liver graft for Liver Transplantation
Sponsors
Eguchi Susumu
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria at the time of consent explanation (1) Patients scheduled to undergo liver transplantation at Nagasaki University Hospital (2) Men or women 18 years of age or older at the time of consent (3) Patients who have given their consent to participate in this study Secondary inclusion criteria at the time of transplantation decision (1) Patients whose transplantation has been decided (2) Patients who have given verbal consent for the continuation of the study (3) Donors who meet any of the following criteria (a) 60 years of age or older (b) expected cold ischemic time for more than 9 hours (including minimum HOPE duration of 1 hour) (c) diagnosis of fatty liver by US/CT (d) any of the following liver function abnormalities - T.Bil highest value of 3 mg/dL or higher - T.Bil immediately before 3 mg/dL or higher - AST/ALT highest value of 1, 000 IU/L or more - AST/ALT immediately preceding value of 100 IU/L or more
Exclusion criteria
Exclusion criteria: Exclusion criteria at the time of explanation (1) When it is expected to be difficult to insert a perfusion tube due to the morphology or condition of the blood vessels. (2) The patient's condition is unstable and it is judged that transplantation should be performed as soon as possible. (3) For reasons other than the above, when the investigator judges that machine perfusion is undesirable based on an overall assessment of the patient's condition. Secondary exclusion criteria at the time of transplantation decision (1) The patient's intraoperative condition is unstable, and it is judged that transplantation should be performed as soon as possible. (2) For reasons other than the above, the investigator judges that mechanical perfusion is undesirable based on a comprehensive judgment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Completion rate of machine perfsuion | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of serious complications within 30 days Incidence of Post-reperfusion syndrome 3-month graft survival rate | — |
Contacts
Public ContactSusumu Eguchi
Nagasaki University Hospital
Outcome results
None listed