A Study of the Efficacy of HFNC in Maintaining Oxygenation in Persons Undergoing Dental Treatment under Intravenous Sedation

A Study of the Efficacy of High Flow Nasal Cannula in Maintaining Oxygenation in Persons Undergoing Dental Treatment under Intravenous Sedation - A Study of the Efficacy of High Flow Nasal Cannula in Maintaining Oxygenation in Persons Undergoing Dental Treatment under Intravenous Sedation

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCTs072240107

Enrollment

144

Registered

2025-02-06

Start date

2025-02-06

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

dental caries

Interventions

Eligible patients who meet enrollment requirements will be randomly assigned to one of two groups after consent is obtained: the HFNC group and the LFNC group. Both groups will use the same standard n

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Patients scheduled to undergo dental treatment (generally within 2 hours) at the implementing medical institution 2) Patients undergoing dental treatment under sedation using a combination of midazolam and propofol 3) Men and women who are between 18 and 85 years of age at the time of consent. 4) Patients who have received a thorough explanation of their participation in this study, and who have given written consent of their own free will based on sufficient understanding.

Exclusion criteria

Exclusion criteria: 1) Patients receiving continuous oxygen administration via nasal cannula (home oxygen therapy) 2) Patients with a history of pneumothorax 3) Patients with a history of bronchial asthma attack or severe asthma 4) Patients participating in clinical trials or other clinical studies 5) Patients who are judged to be inappropriate as research subjects by the principal investigator and subinvestigators.

Design outcomes

Primary

Measure	Time frame
Incidence of Hypoxemia (SpO2 < 90%)	—

Secondary

Measure	Time frame
1)Mean respiratory rate during sedation (an indirect measure of carbon dioxide accumulation) 2)Doses of sedative drugs (midazolam and propofol) per unit hour of anesthesia 3)Ramsay scale, an objective sedation assessment 4)Incidence of severe hypoxemia (SpO2 < 80%) 5)Number of oxygen flow changes for respiratory support devices (NHF, LFO) 6)Average flow used by NHF, and average FiO2 used (continuously recorded with AIRVO3) 7)Percentage of occurrences of sustained hypoxemia (definition: an event of hypoxemia (SpO2 < 90%) lasting more than 10 seconds) 8) Airway clearance interventions (mandibular and ottogai elevation, with or without and frequency of forward mandibular movement)	—

Measure

Time frame

1)Mean respiratory rate during sedation (an indirect measure of carbon dioxide accumulation) 2)Doses of sedative drugs (midazolam and propofol) per unit hour of anesthesia 3)Ramsay scale, an objective sedation assessment 4)Incidence of severe hypoxemia (SpO2 < 80%) 5)Number of oxygen flow changes for respiratory support devices (NHF, LFO) 6)Average flow used by NHF, and average FiO2 used (continuously recorded with AIRVO3) 7)Percentage of occurrences of sustained hypoxemia (definition: an event of hypoxemia (SpO2 < 90%) lasting more than 10 seconds) 8) Airway clearance interventions (mandibular and ottogai elevation, with or without and frequency of forward mandibular movement)

—

Contacts

Public ContactTakao Ayuse

Nagasaki University Hospital

ayuse@nagasaki-u.ac.jp+81-958197713

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026