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Efficacy of Nasal High Flow therapy on the coordination between breathing and swallowing of saliva during daytime nap in COPD patients.

Efficacy of Nasal High Flow therapy on the coordination between breathing and swallowing of saliva during daytime nap in COPD patients. A single center, randomized crossover controlled study.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-jRCTs072200014
Enrollment
15
Registered
2020-05-21
Start date
2020-05-21
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COPD

Interventions

Sponsors

Ayuse Takao
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: The severity of COPD is moderate (GOLD2) or more. Age: At the time of obtaining consent, an adult patient 40 years or older Gender: Any Hospitalization / Outpatient: Outpatient only Patients who have been given sufficient explanations to participate in this study and have given their full understanding and informed consent from the patient

Exclusion criteria

Exclusion criteria: Patients who cannot breathe nose Patients with a history of pneumothorax Patients with active malignancy Patients with acute disease (such as acute myocardial infarction) Patients currently diagnosed with asthma (Patients who have a history of asthma but are currently diagnosed with COPD are eligible for inclusion.) Patients who have been diagnosed with obstructive sleep apnea in the past and who are strongly suspected clinically Patients already using NHF Patients who are using non-invasive ventilation (NIV) at night Patients with severe disease of the kidney, liver or circulatory system Patients who are considered inappropriate by the Principal Investigator Patients who are positive for the new coronavirus (SARS-CoV-2) PCR test

Design outcomes

Primary

MeasureTime frame
Rate of expiratory phase after swallowing saliva

Secondary

MeasureTime frame
1) Time-weighted average value of tcpO2 (average partial pressure during observation period) 2) Time-weighted average value of tcpCO2 (average partial pressure during observation period) 3) Time-weighted average value of SpO2 (average oxygen saturation during observation period) 4) Time-weighted average respiratory rate (average respiratory rate during the observation period)

Contacts

Public ContactTakao Ayuse

Nagasaki University Hospital

ayuse@nagasaki-u.ac.jp+81-958197713

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026