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Study on prevention of hypercapnia by Nasal High Flow in patients with endoscopic submucosal dissection during intravenous anesthesia

Study on prevention of hypercapnia by Nasal High Flow in patients with endoscopic submucosal dissection during intravenous anesthesia

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-jRCTs072190022
Enrollment
104
Registered
2019-08-26
Start date
2019-12-25
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Esophagus cancer, Gastric cancer, Colorectal cancer

Interventions

Sponsors

Ayuse Takao
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1 Age: Adult patients aged 20 to 85 years of age at the time of consent acquisition 2 Gender: Any question 3 hospitalization / outpatient: hospitalization only 4 Patients who received written consent by their own free will after thorough understanding before participating in this study

Exclusion criteria

Exclusion criteria: 1 Continuous administration of oxygen by nasal cannula (home oxygen therapy) 2 Patients who cannot breathe in the nose Patients who need to stop antithrombotic drugs before 3 endoscopes 3 Patients who cannot reduce or stop the antithrombotic drug on the day before the endoscope 4 Patients with a history of pneumothorax 5 Other patients judged by the research director as inappropriate for study 6 Patients who are positive for the new coronavirus (SARS-CoV-2) PCR test

Design outcomes

Primary

MeasureTime frame
1) Occurrence of marked hypercarbonemia showing maximum value of percutaneous carbon dioxide concentration over 60 mmHg (equivalent to PaCO2> 55 mmHg) during intravenous anesthesia 2) Area under curve (AUC) of percutaneous carbon dioxide concentration per unit time at intravenous anesthesia 3) Duration of moderate hypercarbonemia showing maximum value of 50mmHg or more (equivalent to PaCO2> 45mmHg) during percutaneous anesthesia with intravenous anesthesia 4) Occurrence of hypoxemia showing 90% or less of the value of percutaneous oxygen saturation during intravenous anesthesia

Secondary

MeasureTime frame
1) Anesthesia depth assessment (Ramsay scale) 2) Anesthesia dose

Contacts

Public ContactTakao Ayuse

Nagasaki University Hospital

ayuse@nagasaki-u.ac.jp+81-95-819-7713

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026