Effects of perioperative administration of synthetic steroid on glycometabolism and insulin resistance

Effects of perioperative administration of synthetic steroid on glycometabolism and insulin resistance - steroid on glycometabolism and insulin resistance

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCTs072180082

Enrollment

Registered

2019-03-28

Start date

2018-10-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

disorders in oral surgery field

Interventions

steroid group: betamethasone 0.2mg/kg is administrated intravenously right after tracheal intubation control: normal saline 0.05ml/kg is administrated intravenously right after tracheal intubation

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. written informed concent is obtained from patients who undergo oral surgery 2. aged from 20 to 50 3. ASA from 1 or 2 4. estimated operation time:3-7 hours

Exclusion criteria

Exclusion criteria: 1. patients diagnosed with diabetes mellitus or disorder of carbohydrate metabolism 2. 18.0>BMI BMI<=30 3. patients suspicious of cancer or cancerous patients 4. patients who should not receive rinderon 5. patients whom reseachers consider inappropriate

Design outcomes

Primary

Measure	Time frame
insulin resistance	—

Secondary

Measure	Time frame
change of blood glucose during general anesthesia, blood test (lactate, pyruvic acid, insulin, free fatty acid, ketone body, catecholamine, 3-methylhistidine(indicator of muscle protein degradation,cortisol), serum electrolyte(Na+,K+,Mg2+,Ca2+,Cl-),arterial blood gas (pH,PaCO2,PaO2,HCO3-,BE), urea nitrogen	—

Contacts

Public ContactSayuri Kadowaki

3-1-1 Maidashi Higashi-ku Fukuoka

s.koyama@dent.kyushu-u.ac.jp+81-92-642-6480

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026