Major depression, bipolar disorder
Conditions
Interventions
rTMS 5 session a week, 30 trains for 6 weeks in total. Cerebrospinal fluid test is performed before and after rTMS.
Sponsors
Tateishi Hiroshi
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Patients with major depression or bipolar disorders who were ineffective for the treatment of more than one antidepressants 2.Written informed consent
Exclusion criteria
Exclusion criteria: Absolute contraindications are patients with metals in the brain, patients with intracardiac catheters, patients with high intracardiac pressure. Relative contraindications are epilepsy patients, patients with a history of intracranial lesions, oral history of drugs that reduce convulsion threshold, sleep deprivation, alcohol dependence, pregnant women, children, patients with severe heart disease. Regarding cerebrospinal fluid examination, patients with high risk such as bleeding tendency, heparin use, anesthesia allergy, cerebral hypertension etc., or patients judged inappropriate by the psychiatrist.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The efficacy of rTMS for patients with refractory mood disorders | — |
Secondary
| Measure | Time frame |
|---|---|
| The changes of BDI , biomarkers in cerebrospinal fluid, blood and saliva, fractional anisotropy value, cerebral blood flow rate, cerebral cortex blood flow and oxygen consumption, frontal lobe function, electroencephalogram and their correlation. | — |
Contacts
Public ContactKeisuke Saruwatari
Faculty of Medicine, Saga University
Outcome results
None listed