chronic coronary syndrome
Conditions
Interventions
PHGG (SunFiberR) at a dose of 6g per serving, three times a day after each meal, for a duration of 28 days
Sponsors
Tsujita Kenichi
Matsuzawa Yasushi
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Age 40 to 90 years old of chronic coronary syndrome (2) Not taking dietary fiber supplements or probiotics for a month (3) Written consent for participation to this study
Exclusion criteria
Exclusion criteria: 1)under taking antibiotics 2)inflammatory bowel disease 3)those with uncontrolled diabetes mellitus (HbA1c(NGSP) > 9.0% 4)active malignant disease 5)hematological disease 6)receiving steroid therapy within a month 7)patients who are pregnant, breastfeeding (including those planning to discontinue breastfeeding), or who intend to become pregnant during the course of the clinical trial 8)patients who are enrolled or planned to participate in another clinical trials 9)others, patient judged inappropriate by the attending Physician 10)elderly patients with low medication compliance, dementia, or swallowing dysfunction
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pre and post serum TMAO(Tri-methylamine N-oxide)levels | — |
Secondary
| Measure | Time frame |
|---|---|
| 16S ribosomal RNA gene analysis of gut microbiota endothelial function test (EndoPAT), T-TAS, defecation frequency, Bristol stool scale, CRP, glucose, serum lipids | — |
Contacts
Public ContactKenichi Tsujita
Kumamoto University Hospital
Outcome results
None listed