Anorexia Nervosa Anorexia Nervosa
Conditions
Interventions
Randomized controlled trial: AN patients will be randomly assigned to receive SynB or placebo, and the treatment effect will be evaluated at baseline, 6 weeks after starting, and 12 weeks after starti
Sponsors
Sudo Nobuyuki
Hata Tomokazu
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1) Persons who have given written consent of their own free will 2) Female inpatients who are at least 12 years old and less than 49 years old at the time consent is obtained 3) Patients who meet the diagnostic criteria for the diagnosis of neurotic emaciation in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) published by the American Psychiatric Association in a structured interview. Any duration of illness is acceptable. 4) Patients who are less than 75% of standard body weight and eligible for our inpatient treatment program "Cognitive Behavioral Therapy with Behavioral Restraints" (patients who are not in a state of physical crisis and are capable of restoring nutritional status and working on psychological tasks)
Exclusion criteria
Exclusion criteria: 1) Patients with known complications of physical illness or other psychiatric disorders (such as schizophrenia or bipolar disorder) 2) Patients who have received antibiotics or treatment with central venous nutrition within 3 months prior to entry 3) Patients with arrhythmias or infections due to extremely low nutrition, or in a state of physical crisis (electrolyte abnormalities with panic values such as sodium below 120 mEq/L and potassium below 2.5 mEq/L)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Compare "weight gain per energy intake" to verify the superiority of SynB administration. | — |
Secondary
| Measure | Time frame |
|---|---|
| Questionnaire: changes in mental and physical symptoms, blood tests, enterobacterial analysis (fecal, blood), metabolome analysis, uremic toxin measurement, microRNA analysis, EEG, MRI analysis. | — |
Contacts
Public ContactTomokazu Hata
Department of Psychosomatic Medicine, Kyushu University Hospital
Outcome results
None listed