Intubated patients after oral surgery Oral surgery
Conditions
Interventions
One application of tetracycline hydrochloride ointment on the back of the tongue.
topical antibiotics administration
Sponsors
Miura Kei-ichiro
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Oral surgery patients who are managed under intubation by postoperative tracheotomy at Nagasaki University Hospital Oral Surgery or Hiroshima University Hospital Oral and Maxillofacial Surgery between the date of jRCT publication and December 28, 2023. 2. Patients who can personally provide written consent at their own free will after being receiving a thorough explanation of the study and fully understanding their participation in the study.
Exclusion criteria
Exclusion criteria: Any of the following patients will be excluded: 1. Patients with past history of allergy for the tetracycline hydrochloride and ampicillin sodium sulbactam sodium 2. Partients who are judged to be inappropriate to participate the study by the principal or cooperative doctors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bacterial counts in oropharyngeal fluid and retained fluid on the cuff before administration and 1, 2, 3, and 6 hours after administration | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Antimicrobial drug concentrations in oropharyngeal fluid and supra-cuff fluid before administration and 1, 2, 3, and 6 hours after administration 2. Development of postoperative pneumonia 3. Safety of antimicrobial pharmacy administration | — |
Contacts
Public ContactKei-ichiro Miura
Nagasaki University Hospital
Outcome results
None listed