Patients receiving high-dose antiresorptive agent high-dose antiresorptive agent, osteonecrosis
Conditions
Interventions
Insert of antimicrobial(MINOCYCLINE) penetrated collargen plug(TERUPLUG) for post-extraction tooth socket, close the wound.
Sponsors
Omori Keisuke
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients receiving ZOMETA or RANMARK therapy who are planned to undergo tooth extraction 2. Patients who received sufficient explanation in participating in this study, and obtained written consent by the patient's free will after sufficient understanding.
Exclusion criteria
Exclusion criteria: 1. Patients with a history of hypersensitivity to tetracycline antibiotics or animal proteins in the past 2. Patients receiving walfarin potassium, sulfonylurea hypoglycemic agents, methotrexate, porphymer sodium, digoxin, luteal / follicular hormone combination drug, oral contraceptives, vitamin A preparations and retinoid preparations excluding external preparations 3. Other patients who are judged by the principal investigator to be inappropriate as research subjects
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MRONJ onset rate 2 months after tooth extraction in each group | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. quantification of total bacterial count by real-time PCR method 2. adverse events related to study drugs and medical devices (hypersensitivity symptoms, inflammatory changes such as redness and swelling of the oral mucosa) | — |
Contacts
Public ContactKeisuke Omori
Nagasaki University Hospital
Outcome results
None listed