non-small cell lung cancer non-small cell lung cancer
Conditions
Interventions
chemoradiation with use of weekly carboplatin and concurrent radiotherapy
Sponsors
Harada Taishi
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1)Patients with histologically or cytologically confirmed non-small cell lung cancer. 2)No prior history of chemotherapy, thoracic radiotherapy or surgical resection 3)Unresectable stage 3disease. 4)V20 is under 35%. 5)There is measurable region. 6)Age>=75 7)Eastern Cooperative Oncology Group performance status==4000/mm3, Neutrocyte>=2000/mm3, platelets>=100000/mm3, hemoglobin>=9.0g/dl, AST and ALT==65torr or SpO2>=92% 9)Written informed consent.
Exclusion criteria
Exclusion criteria: 1)Involvement of contralateral hilar lymph nodes. 2)Interstitial pneumonia or pulmonary fibrosis detected with chest X-ray. 3)SVC syndrome. 4)Obstructive pneumonia or active severe infection. 5)Other active invasive malignancies 6)Severe complications such as gastrointestinal bleeding, significant heart failure or uncontrolled diabetes and so on. 7)History of severe hypersensitivity. 8)Regular use of corticosteroids. 9)Mental illness 10)Pregnant woman and lactating woman 11)Active hepatitis B 12)A case considered by an investigator inadequate for the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Response rate | — |
Secondary
| Measure | Time frame |
|---|---|
| Progression-free survival, overall survival, maintenance therapy shift rate, safety, response rate (no confirmation) during chemotherapy / concurrent chest radiotherapy | — |
Contacts
Public ContactTaishi Harada
Japan Community Health care Organization Kyushu Hospital
Outcome results
None listed