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Investigation of the preventive effects of antimicrobial penetrated collargen plug(TERUPLUG) for post-extraction tooth socket for osteonecrosis of the jaw after tooth extraction in patients using high-dose antiresorptive agent

Investigation of the preventive effects of antimicrobial penetrated collargen plug(TERUPLUG) for post-extraction tooth socket for osteonecrosis of the jaw after tooth extraction in patients using high-dose antiresorptive agent

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
JPRN
Registry ID
JPRN-jRCTs071200006
Enrollment
30
Registered
2020-04-20
Start date
2020-07-02
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients receiving high-dose antiresorptive agent high-dose antiresorptive agent, osteonecrosis

Interventions

Intervention group: Insert of antimicrobial(MINOCYCLINE) penetrated collargen plug(TERUPLUG) for post-extraction tooth socket, close the wound, and remove sutures 1 week later. Control group: Insert o

Sponsors

Soutome Sakiko
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Patients receiving ZOMETA or RANMARK therapy who are planned to undergo tooth extraction

Exclusion criteria

Exclusion criteria: Patients with problem in judgement

Design outcomes

Primary

MeasureTime frame
Incidence of MRONJ 2 months later after tooth extraction—

Secondary

MeasureTime frame
Association of investigation factors and onset of MRONJ—

Contacts

Public ContactSakiko Soutome

Nagasaki University Hospital

sakiko@nagasaki-u.ac.jp+81-95-819-7698

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026