decompensated cirrhosis
Conditions
Interventions
Control group (A)
Participants allocated to the control group will undergo only NMES within 7 days after LDLT for 1 month in addition to their previous treatment.
EMS and BCAA group (B)
Participants allocated to the NMES and BCAA group will undergo EMS within 7 days after LDLT and take BCAA-enriched snack at 100 mg/day
Sponsors
Miyaaki Hisamitsu
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) an individual age; more than 20 years (2) diagnosed with decompensated liver cirrhosis (3) Performance Status (PS); 0 to 2 (4) providing written informed consent
Exclusion criteria
Exclusion criteria: (1) complicated with a bone or a joint disorder that might affect the affect the effectiveness of EMS (2) complicated with fragile skin disease that might cause skin damage due to EMS (3) complicated with cerebrovascular disorder (4) patients undergoing hemodialysis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| changes in the skeletal muscle mass from baseline (day 0) to day 90 post LDLT. | — |
Secondary
| Measure | Time frame |
|---|---|
| (1) The changes in the skeletal muscle index (SMI), SMM, quadriceps strength and quadriceps muscle thickness from baseline to day 30 post LDLT. (2) changes in the SMI and quadriceps from baseline (day 0) to day 90 post LDLT. (3) The changes in the phase angle, visceral fat area, and handgrip strength from baseline to day 30 post LDLT. | — |
Contacts
Public ContactMasafumi Haraguchi
Nagasaki University Hospital
Outcome results
None listed