Congenital toxoplasmosis
Conditions
Interventions
Sponsors
Maruyama Haruhiko
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Confirmed toxoplasmosis fulfilling one of the followings #1 Toxoplasma DNA detected in placenta or other tissues #2 pathological identification of Toxoplasma #3 anti-Toxoplasma IgM in cord blood or sera within 6 months after birth #4 increase of anti-Toxoplasma IgG within 1 year after birth #5 positive anti-Toxoplasma IgG after 12 months after birth 2. Suspected toxoplasmosis with all of the followings #1 typical symptoms (e.g. intra-cranial calcification) #2 positive anti-Toxoplasma IgG #3 other congenital infections excluded
Exclusion criteria
Exclusion criteria: #1 HIV positive patients #2 patients allergic to test compounds #3 patients with megaloblastic anemia due to folate deficiency #4 No consent is given from the patient him/herself nor a legally authorized representative/guardian of the patient #5 patients principal investigator judged inappropriate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of psychomotor retardation | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) incidence of new ocular lesions 2) incidence of auditory disorder 3) incidence of hydrocephalus 4) incidence of abdominal symptoms 5) incidence of pancytopenia 6) incidence of acute renal failure 7) incidence of hepatic dysfunction 8) incidence of skin eruption (e.g. erythema) | — |
Contacts
Public ContactKei Yamamoto
Japan Institute for Health Security National Center for Global Health and Medicine
Outcome results
None listed