Influence of therapeutic agent for glaucoma on biological clock

Influence of therapeutic agent for glaucoma on biological clock in healthy adult male - Influence of therapeutic agent for glaucoma on biological clock in healthy adult male

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCTs071180026

Enrollment

Registered

2019-02-28

Start date

2019-03-29

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Interventions

A part: Instillation of Xalatan Eye Drops 0.005% or placebo to both eye (1 drop/eye, 1 drop/day, 17:00) B part: Swabbing of Xalatan Eye Drops 0.005% or placebo on jaw (3 cm*3 cm) by cotton (1 drop/jaw

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: 1. Written informed consent 2. No shift work, no overseas travel during the study 3. Detection of cortisol in saliva

Exclusion criteria

Exclusion criteria: 1. Steroid administration 2. Overseas travel before the study 3. Sleeping pill administration 4. Delayed sleep phase syndrome

Design outcomes

Primary

Measure	Time frame
1. Cortisol concentration in saliva 2. Clock gene expression level in hair follicle 3. Electroretinogram	—

Secondary

Measure	Time frame
Adverse events, vital sign	—

Contacts

Public ContactNoritomo Izumi

SOUSEIKAI Hakata Clinic

noritomo-izumi@lta-med.com+81-92-283-7701

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026