depression
Conditions
Sponsors
Okada Go
Aurelio Cortese
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients with major depressive (1) Aged 18-60 years old (2)Being diagnosed as depression (currently meeting the criteria for a depressive episode) according to DSM-5 criteria (3)Written consent for participation has been obtained from the participant him/herself
Exclusion criteria
Exclusion criteria: (1) Decisionally impaired individuals who has diminished capacity to understand the aim of the research (2) Physically impaired individuals who are not able to complete the experiment (3) Subjects who are contraindicated for the use of MRI Having an implanted heart pace-maker Having implanted cerebral (arteries) clips Having implanted neural/nerve stimulators Having implanted pumps Having work experience in a metal industry or possibility of metal residues remaining in the body Having metal-tattoos (including tattooed eye-lining) Being pregnant, or having possibility of being pregnant MRI claustrophobia (4)Those who have received NF, mECT, or rTMS within the past 1 year (5)Any individuals judged as inappropriate for the experiment by the principal investigator or a collaborating researcher
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| (1) Change from baseline in symptom A (assessed by HRSD and BDI-II) when neurofeedback targeting functional coupling A (2) Change from baseline in symptom B (assessed by HRSD and BDI-II) when neurofeedback targeting functional coupling B | — |
Secondary
| Measure | Time frame |
|---|---|
| (1) Anxiety symptoms: Change from baseline in anxiety symptoms (assessed by STAI). STAI is a self-administered questionnaire test that measures anxiety by dividing it into two factors: state anxiety and trait anxiety. (2) Rumination symptoms: Change from baseline in rumination symptoms (assessed by RRS). RRS is a self-administered questionnaire test. (3) Cognitive function: Change from baseline in cognitive function (as assessed by the Cambridge Neuropsychological Test Automated Battery (CANTAB). CANTAB is a computer-based test battery developed to evaluate cognitive function, and is performed on a touch-panel iPad. (4) Social cognitive function: Changes from the baseline of EBT (Emotion Bias Task). EBT is a computer-based test battery administered using a touch panel mobile device. | — |
Contacts
Public ContactGo Okada
Hiroshima University
Outcome results
None listed