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Study of the efficacy of root sealing with MTA cement

Evaluation of the efficacy of mineral trioxide aggregate cement sealing to a root canal with apical destruction.

Status
Recruiting
Phases
Phase 1
Study type
Interventional
Source
JPRN
Registry ID
JPRN-jRCTs062220103
Enrollment
12
Registered
2023-02-28
Start date
2023-06-23
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

apical periodontitis apical periodontitis

Interventions

Seal the root canal up to 3-5 mm from the apex with MTA cement.
MTA cement

Sponsors

Saito Noriko
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Ages 18 old over or older with written informed consent from the individual 2. Outpatients who can come in for treatment and follow-up 3. Patients with a single root and a single root canal with a radiographic transparency of the root apex before treatment and an enlarged root apex of 0.55 to 0.80 mm

Exclusion criteria

Exclusion criteria: 1. patients with severe clenching and bruxism 2. patients with root fractures 3. patients with periodontal-endodontic lesions and endodontic-periodontal lesions 4. patients with perforations 4. patients with perforations 5. patients with a history of hypersensitivity, such as rash or dermatitis, to chemical substances, including raw materials of the materials under study 6. patients who are participating or intend to participate in other clinical research studies during the course of participation in this study Patients who are deemed to interfere with, limit, or confound the evaluation specific to the clinical research protocol. 8. 8. a principal investigator or employee of the institution directly involved in this or other clinical research, or a family member of such an employee, principal investigator, etc. 9. patients with findings of suspected root cysts or root granulomas in the subject tooth 10. patients who are or may be pregnant 11. patients whose clinical symptoms (spontaneous pain, bruxism, gingival redness and swelling, fistula) do not resolve after several standard root canal procedures

Design outcomes

Primary

MeasureTime frame
Percentage of patients with reduced or eliminated root tip bone defect volume calculated from dental CBCT images

Secondary

MeasureTime frame
Evaluation of periapical tissue healing tendency using dental radiographs based on the PAI score

Contacts

Public ContactNoriko Saito

Hiroshima University Hospital

r14saito@hiroshima-u.ac.jp+81-82-257-5656

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026