Subarachnoid hemorrhage ,severe cerebral infarction , severe head trauma , severe cerebral hemorrha
Conditions
Interventions
1)Placement of subdural electrodes or multimodal sensor
1.After confirmation of inclusion criteria and informed consent for the patients with subarachnoid hemorrhage (SAH),the subdural electrodes or t
Sponsors
Nomura Sadahiro
Suzuki Michiyasu
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1)Man or woman patients aged 20 years or more 2)Patients who admitted Yamaguchi University Hospital 3)Patients who received sufficient information and understand on the inclusion. Patients or family member agreed to join the research under free will. 4)Patients with the following diseases 1.Patients with SAH going to be operated with aneurysmal surgery by 3 days from the onset. 2.Patients with severe cerebral infarction going to be operated with decompressive craniectomy by 48h from the onset. 3.Patients with severe neurotrauma with GCS 8 or less, going to be operated with decompressive craniectomy. 4.Patients with cerebral hemorrhage going to be operated because of brain swelling or large hemorrhage.
Exclusion criteria
Exclusion criteria: 1)Patients suspected immunodeficiency due to steroids or immunosuppressing agents 2)Patients whom the research leader decides not to optimal to include the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Frequency of appearance and duration of the spreading depolarization. Neurological outcome of the patients 30 days and 180 days after the onset, assessed by mRS and GOS | — |
Secondary
| Measure | Time frame |
|---|---|
| Assessment of the safety and worsening sign in the blood and neuroradiological examinations. Changes in cerebral blood flow and brain temperature during the occurrence of the spreading depolarization will be analyzed for investigation of the pathophysiology. | — |
Contacts
Public ContactSadahiro Nomura
Yamaguchi University Hosptal
Outcome results
None listed