Effects and safety of narrowband UVB irradiation on gene expression of histamine H1 receptor and allergy-related cytokine in nasal mucosa of patients with allergic rhinitis: an early phase 2 study

Effects and safety of narrowband UVB irradiation on gene expression of histamine H1 receptor and allergy-related cytokine in nasal mucosa of patients with allergic rhinitis: an early phase 2 study - An early phase 2 study of narrowband UVB

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCTs062180049

Enrollment

Registered

2019-03-14

Start date

2018-02-26

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Allergic rhinitis

Interventions

A single intranasal irradiation with narrowband UVB (310 nm) irradiation at a dose of 600 mJ/cm2 using phototherapy device equipped with LED (developed by Daiichi Medical).

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Adult patients aged 20 or above. 2) Patients who were diagnosed as allergic rhinitis.

Exclusion criteria

Exclusion criteria: 1) Patients with serious complications 2) Patients who was excluded by investigators

Design outcomes

Primary

Measure	Time frame
Changes in mRNA levels of histamine H1 receptor and allergy-related cytokines such as IL-4, 5 and 33.	—

Secondary

Measure	Time frame
Nasal symptoms and macroscopic findings of nasal mucosa.	—

Contacts

Public ContactYoshiaki Kitamura

Tokushima University

ykitamura@tokushima-u.ac.jp+81-88-633-7169

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026