Effects and safety of narrowband UVB irradiation on gene expression of histamine H1 receptor and allergy-related cytokine in nasal mucosa of healthy subjects: a phase 1 study

Effects and safety of narrowband UVB irradiation on gene expression of histamine H1 receptor and allergy-related cytokine in nasal mucosa of healthy subjects: a phase 1 study - A phase 1 study of narrow-band UVB

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCTs062180048

Enrollment

Registered

2019-03-14

Start date

2017-09-14

Completion date

Unknown

Last updated

2025-07-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

non non

Interventions

A single intranasal irradiation with narrowband UVB (310nm) irradiation at a dose of 600mJ/cm2 using phototherapy devise equipped with LED (developed by Daiichi Medical)

narrowband UVB

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Adult subjects aged 20 or above 2) Healthy subjects without allergic rhinitis and taking any anti-allergic medications

Exclusion criteria

Exclusion criteria: 1) Subjects with serious complications 2) Subjects who was excluded by investigators

Design outcomes

Primary

Measure	Time frame
Nasal symptoms and macroscopic findings of nasal mucosa	—

Secondary

Measure	Time frame
Changes in mRNA levels of histamine H1 receptor and allergy-related cytokines such as IL-4, 5 and 33	—

Contacts

Public ContactYoshiaki Kitamura

Tokushima University

ykitamura@tokushima-u.ac.jp+81-88-633-7169

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Feb 4, 2026