lung cancer
Conditions
Interventions
Before surgery for lung cancer, take up to three 200 ml bottles of Meiji MEIN per day (morning, noon, and evening, or as needed) orally. The dose should be taken continuously from 14 days prior to the
Sponsors
Shien Kazuhiko
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. The subject has received a full explanation of the contents of the study and has given written consent. 2. Age at the time of consent: 18 years or older 3. Anatomical surgical resection (segmentectomy or lobectomy) for lung cancer or suspected lung cancer is planned. 4. One or more of the following a) to c) are met a) Patient has low pulmonary function (FEV1.0% <70%) or interstitial shadows on imaging. b) Patient has undergone preoperative treatment for lung cancer c) Patient has findings suggestive of malnutrition (BMI < 20 kg/m2 or Alb < 3.5 g/dL).
Exclusion criteria
Exclusion criteria: 1. Patients with diabetes requiring drug therapy or HbA1c of 6.5% or higher 2. Abnormal liver function (AST [GOT]or ALT [GPT] more than twice the institutional standard) 3. Abnormal renal function (eGFR 25 kg/m2) 5. History of allergy to milk or soy 6. Taking other nutritional supplements for caloriereplacement 7. Pregnant or lactating woman, positive pregnancy test, or no intention to use contraception 8. Other patients who are deemed inappropriate for this study by the principal investigator or subinvestigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change rate of preoperative PNI | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Preoperative nutritional and metabolic indices (NLR, CAR, GPS, BMI, muscle mass, etc.) and change rate 2. Postoperative outcomes (duration of postoperative thoracic drainage, postoperative complication rate, postoperative hospital stay, 1-year recurrence-free survival, and overall survival) 3. Changes in tumor microenvironment and microbiome including gut microbiota in preoperative biopsy and surgical resection specimens 4. Status of drug use and symptoms associated with drug use | — |
Contacts
Public ContactKazuhiko Shien
Okayama University Hospital
Outcome results
None listed