olfactory disorder olfactory disorder
Conditions
Interventions
Local administration of bFGF-impregnated gelatin hydrogel to the olfactory cleft on the first day of treatment
local administration
Sponsors
Hato Naohito
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients with olfactory disorder treatment started between 4 weeks and 1 year after onset of olfactory disorder can be evaluated three months after treatment Patients with olfactory impairment with an average cognitive threshold of 2.6 or higher on the T&T olfactometer age of at least 20 to under 65 years old Written informed consent
Exclusion criteria
Exclusion criteria: When the patient cannot come to the hospital Cases with confirmed central olfactory disorders or other nasal sinus diseases (such as olfactory neuroblastoma) Cases judged inappropriate by the attending physician Patients with a history of allergy to gelatin or trafermin Patients who cannot take Tokisyakuyakusan
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvements in average cognitive thresholds three months after treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| Mean cognitive threshold and change in standard olfaction test after 1 month of treatment Percentage of "cured" and "mildly cured" after 3 months of treatment Mean cognitive threshold and amount of change after 3 months of treatment by severity Amount of change in open essences 1 month and 3 months after onset Daily Smell Questionnaire and Olfactory Disorder VAS scores at 1 month and 3 months after onset | — |
Contacts
Public ContactKunihide Aoishi
Ehime University Hospital
Outcome results
None listed