Effect of hydrogen-containing jelly on periodontal tissue

The effect of oral ingestion of hydrogen-containing jelly on periodontal tissue

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCTs061230042

Enrollment

Registered

2023-08-02

Start date

2023-08-05

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontitis

Interventions

Hydrogen-containing jelly group: Hydrogen-containing jelly is swallowed without chewing three times a day (morning, noon, night) for 28 consecutive days. Hydrogen-free jelly (placebo) group: Hydrogen-

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Persons over 70 years old 2. Persons who have more than 10 teeth 3. Persons with periodontitis

Exclusion criteria

Exclusion criteria: 1. Persons who took antibiotics, anti-inflammatory drugs, antiallergic drugs within the past two weeks 2. Persons who drink hydrogen water regularly 3. Persons who have gelatin allergy 4. Persons who have difficulty in swallowing

Design outcomes

Primary

Measure	Time frame
Percentage of sites of bleeding on probing	—

Secondary

Measure	Time frame
Probing pocket depth, clinical attachement level, periodontal inflamed surface area: PISA, plaque control record: PCR, oxidative stress (d-ROMs) and antioxidant capacity (OXY-adsorbent test) of serum oxidative stress, lactate dehydrogenase of unstimulated saliva, cytokines (IL-1 beta, IL-6, IL-10, IL-17, and TNF-alpha) levels of gingival crevicular fluid	—

Contacts

Public ContactMaruyama Takayuki

Okayama University Hospital

t-maru@md.okayama-u.ac.jp+81-86-235-6712

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026