Postoperative pulmonary fistula air leakage
Conditions
Interventions
Intrapleural administration of minocycline (300 mg) with 1% xylocaine 10 mL and 200 mL saline via chest tube
Second administration of minocycline if pulmonary fistula persists 3 days after the first a
Sponsors
Toyooka Shinichi
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Cases with postoperative pulmonary fistula at the postoperative day 3 2) The drainage from the chest tube are not bloody, purulent or chylous, and the volume of the drainage for 24 hours is 300 mL or less 3) Age of 20 years or older 4) Signed informed consent
Exclusion criteria
Exclusion criteria: 1) Allergy against minocycline 2) Other patients who are unfit for the study as determined by the attending physician
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Frequency of removal of the chest tube after the protocol treatment (intrapleural administration of minocycline, up to twice) If the recurrence of pulmonary fistula is observed within 1 week after the removal of the chest tube, such cases are omitted | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Frequency of adverse events 2) Time period until the recurrence of pulmonary fistula | — |
Contacts
Public ContactKen Suzawa
Okayma University Hospital
Outcome results
None listed