Treatment of halitosis with photodynamic therapy

Evaluation of the treatment of halitosis with photodynamic therapy on tongue surface

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCTs061200060

Enrollment

Registered

2021-03-05

Start date

2021-10-05

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Halitosis Halitosis

Interventions

Toluidine blue will be applied to the posterior two-thirds of the tongue dorsum in 6 locations at 1 cm intervals (the diameter: 5mm) and waits for 5 minutes. Then, the irradiation will be performed ea

Photochemotherapy

Photodynamic therapy

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Persons with halitosis

Exclusion criteria

Exclusion criteria: People with allergies to toluidine blue People who are pregnant or breastfeeding Oral cancr patients

Design outcomes

Primary

Measure	Time frame
Concentration of the volatile sulfur compounds	—

Secondary

Measure	Time frame
Bacteria count of the tongue dorsum Flora of the tongue dorsum Concentration of acetaldehyde Probing pocket depth Percentage of sites with bleeding on probing Plaque Control Record Adverse events and side effects	—

Contacts

Public ContactMorita Manabu

Okayama University Hospital

mmorita@md.okayama-u.ac.jp+81-86-235-6712

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026