lower gastrointestinal disease with surgical indication (regardless of benign or malignant) Lower gastrointestinal surgery, surgical site infection
Conditions
Interventions
Cefmetazole is administered intravenously as prophylactic antibiotics. The dose based on recommendation of the guideline. For patients weighing over 80 kg, use a single dose of 2 grams of cefmetazole.
Lower gastrointestinal surgery, surgical site infection, cefmetazole
Sponsors
Ohge Hiroki
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1 Patients scheduled for elective lower gastrointestinal surgery (regardless of open surgery or laparoscopic surgery) 2 Patients weight over 80 kg and BMI 25 kg/m2 or weight less than 40kg and BMI 18.5 kg/m2 or patients excluding weight and BMI already shown. 3 Patients over 20 years old, regardless of gender 4 Patients who can give written informed consent to participate in this study
Exclusion criteria
Exclusion criteria: 1 Patients with a history of allergies to Cefmetazole 2 Patients with a history of allergies to cephems 3 Patients who take drugs require caution in combination use 4 Patients who are pregnant or nursing 5 Patients with diseases in the brain and spinal cord 6 Patients with renal dysfunction who have creatinine clearance less than 50 ml / min estimated by Cockcroft-Gault equation (Use ideal body weight for patients weighing over 80kg) 7 Patients judged inappropriate for this study by the researcher
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pharmacokinetic parameters (Cmax, AUC, T1/2, Tmax) of drug in plasma, peritoneal fluid and abdominal tissues (peritoneum and subcutaneous adipose tissue) | — |
Contacts
Public ContactUegami Shinnosuke
Hiroshima University graduate school
Outcome results
None listed