ischemic heart disease
Conditions
Interventions
necessity of two imaging modalities for assessment of myocardial ischemia
Sponsors
Yamaguchi Osamu
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. patients with diagnosed or suspected coronary artery disease 2. patients who undergo cardiac CT and ammonia-PET
Exclusion criteria
Exclusion criteria: 1. clinically unstable patients (acute myocardial infarction, unstable angina, malignant arrhythmia, symptomatic heart failure: NYHA >class 2, aortic stenosis: >moderate) 2. known prior myocardial infarction 3. known anaphylactic reaction to iodinated contrast 4. bronchial asthma or uncontrolled hyperthyroidism 5. chronic kidney disease (Cre > 1.5 mg/dl) or hemodialysis 6. patients with chronic atrial fibrillation 7. patients with atrial-ventricular block (2 or 3 degree), sick sinus syndrome 8. pacemaker or internal defibrillator lead implantation 9. pregnancy or lactation 10. previous coronary intervention (within 6 months) 11. contraindication to be-ta blockers 12. previous coronary artery bypass grafting 13. patients who are considered inappropriate by a principal investigator or a member of this project
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. rest/stress myocardial blood flow by CTP (MBF-CTP) & coronary flow reserve by CTP (CFR-CTP), rest/stress myocardial blood flow by PET (MBF-PET) & coronary flow reserve by PET (CFR-PET), 2. prognosis: all cause death, cardiac death, acute coronary syndrome, admission for ischemic heart disease, target lesion revascularization (TLR), target vessel revascularization (TVR) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. angina scale (SAQ: Seattle Angina Questionnaire) 2. qualitative analysis by CTP & PET 3. evaluation of myocardial ischemia with other modalities: MR perfusion, SPECT, echo 4. quantitative flow ratio (QFR) by CTP 5. QCA 6. FFR, iFR 7. contrast medium, radiation dose | — |
Contacts
Public ContactTeruyoshi Uetani
Ehime University Hospital
Outcome results
None listed