Effects of repeated aural stimulation on substance P concentration in blood, saliva and sputum and swallowing function in healthy subjects and patients with dysphagia: a phase 1-2 study

Effects of repeated aural stimulation on substance P concentration in blood, saliva and sputum and swallowing function in healthy subjects and patients with dysphagia: a phase 1-2 study - A phase 1-2 study of effects of capsaicin ointment on substance P and swallowing

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCTs061180080

Enrollment

Registered

2019-03-20

Start date

2013-02-25

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dysphasia

Interventions

Repeated aural stimulation with capsaicin ointment

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Healthy subjects 1) Male and female between the age of 20 and 65 years 2) Healthy subjects without dysphagia Patients with dysphagia 1) Male and female between the age of 20 and 100 years 2) Patients with dysphagia

Exclusion criteria

Exclusion criteria: Healthy subjects 1) Subjects who was excluded by investigators Patients with dysphagia 1) Patients with serious complications 2) Patients who was excluded by investigators

Design outcomes

Primary

Measure	Time frame
Healthy subjects Substance P concentration in blood, saliva and sputum Patients with dysphagia Substance P concentration in blood, saliva and sputum and swallowing function	—

Secondary

Measure	Time frame
Adverse reaction such as otalgia or abnormality of eardrum or ear canal	—

Contacts

Public ContactYoshiaki Kitamura

Tokushima University

ykitamura@tokushima-u.ac.jp+81-88-633-7169

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026