Advanced or recurrent head and neck malignancies Head and neck malignancies, BNCT
Conditions
Interventions
1) Intravenous administration of BPA-fructose complex (500mg/Kg.BW) for 2.5 to 3 hour and blood sampling at the time of just before irradiation. The 10B concentration in the blood was measured by prom
Sponsors
Kamitani Nobuhiko
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) With recurrence head and neck melanoma that surgical treatment is not indicated. 2) The depth of tumor, less than 6cm, and without distant metastases. 3) T/N ratio is more than 2.5 using 18F-BPA-PET. 4) KPS>= 60 percentage 5) Serum creatinine<=1.2mg/dl(male), 1.0mg/dl(female)
Exclusion criteria
Exclusion criteria: 1) Double cancer with disease-free period less than 3 years 2) Distant metastases 3) Active infection 4) Adverse events mere than Grade 3 induced by previous therapy 5) Tumor exposure to the skin and tumor invasion to the carotid artery 6) Severe heart complications 7) Difficulty of patient fixation for irradiation 8) White blood cell<=3000/mm3, Platelet<=100,000/mm3 9) Unsuitable patients for medical or social situation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Tumor response in 6 months after BNCT | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse events in 6 months after BNCT | — |
Contacts
Public ContactNobuhiko Kamitani
Kawasaki Medical School Hospital
Outcome results
None listed