Advanced or recurrent skin malignancies Skin malignancies, BNCT
Conditions
Interventions
1) Intravenous administration of BPA-fructose complex (200mg/Kg.BW) for 2.5 to 3 hour and blood sampling at the time of just before irradiation. The 10B concentration in the blood was measured by prom
Sponsors
Kamitani Nobuhiko
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) With recurrent skin malignancies that surgical treatment is not indicated or is strongly rejected by patient. 2) The depth of tumor is less than 6cm 3) T/N ratio is more than 2.5 using 18F-BPA-PET. 4) Serum creatinine= 60 percentage
Exclusion criteria
Exclusion criteria: 1) Double cancer with disease-free period less than three years 2) Distant metastases 3) Active infection 4) Adverse events mere than Grade 3 induced by previous therapy 5) Severe heart complications 6) Difficulty of patient fixation for irradiation 7) White blood cell<=3000/mm3, Platelet<=100,000/mm3 8) Unsuitable patients for medical or social situation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Tumor response in 6 months after BNCT | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse events in 6 months after BNCT | — |
Contacts
Public ContactNobuhiko Kamitani
Kawasaki Medical School Hospital
Outcome results
None listed