Influence of hydrogen containing jelly on periodontal tissue

Influence of oral ingestion of hydrogen containing jelly on periodontal tissue - Influence of hydrogen containing jelly on periodontal tissue

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCTs061180055

Enrollment

Registered

2019-03-14

Start date

2019-05-17

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

1: Healthy, 2: gingivitis

Interventions

Study on safety of hydrogen-containing jelly: Hydrogen-containing jelly is swallowed three times a day (after every meal) for 14 consecutive days. Investigation of effects on periodontal tissue by or

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Study on safety of hydrogen-containing jelly: 1. Healthy persons over 20 years old Investigation of effects on periodontal tissue by oral ingestion of hydrogen containing jelly: 1. Persons with gingival inflammation with more than 20% of sites of bleeding on probing 2. Persons 20 to 39 years old

Exclusion criteria

Exclusion criteria: Study on safety of hydrogen-containing jelly: 1. Persons who drink hydrogen water regularly 2. Persons who have gelatin allergy 3. Persons who have difficulty in swallowing 4. Women who are pregnant or are likely to become pregnant 5. Lactating women Investigation of effects on periodontal tissue by oral ingestion of hydrogen containing jelly: 1. Persons who took antibiotics, anti-inflammatory drugs, antiallergic drugs within the past two weeks 2. Persons who drink hydrogen water regularly 3. Persons who have gelatin allergy 4. Persons who have difficulty in swallowing 5. Smoker 6. Women who are pregnant or are likely to become pregnant 7. Lactating women

Design outcomes

Primary

Measure	Time frame
Study on safety of hydrogen-containing jelly: adverse side effect Investigation of effects on periodontal tissue by oral ingestion of hydrogen containing jelly: percentage of sites of bleeding on probing	—

Secondary

Measure	Time frame
Study on safety of hydrogen-containing jelly: none Investigation of effects on periodontal tissue by oral ingestion of hydrogen containing jelly: probing pocket depth, clinical attachement level, periodontal inflamed surface area: PISA, plaque control record: PCR, oxidative stress (d-ROMs) and antioxidant capacity (OXY-adsorbent test) of serum oxidative stress (8-OHdG) and lactate dehydrogenase of unstimulated saliva, cytokines (IL-1 beta, IL-6, IL-10, IL-17, and TNF-alpha) levels of gingival crevicular fluid	—

Measure

Time frame

Study on safety of hydrogen-containing jelly: none Investigation of effects on periodontal tissue by oral ingestion of hydrogen containing jelly: probing pocket depth, clinical attachement level, periodontal inflamed surface area: PISA, plaque control record: PCR, oxidative stress (d-ROMs) and antioxidant capacity (OXY-adsorbent test) of serum oxidative stress (8-OHdG) and lactate dehydrogenase of unstimulated saliva, cytokines (IL-1 beta, IL-6, IL-10, IL-17, and TNF-alpha) levels of gingival crevicular fluid

—

Contacts

Public ContactManabu Morita

Okayama University Hospital

mmorita@md.okayama-u.ac.jp+81-86-235-6712

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026