hand symptoms in perimenopause menopausal hand, hand symptoms in perimenopause, hand stiffness, finger joint pain, moring stiffness
Conditions
Interventions
After a 2-week of observation period, participants are requested to wear the holders whith sposable warmers inserted on their bilateral hands during sleeping (warmer adapted on dorsal side of the wris
Sponsors
Shima Yoshihito
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Women between 40 and 59 years old. 2. Persons who are aware of "swelling" or "stiffness" in both hands, or who have pain in two or more finger joints. 3. Persons who have given written consent to participate in the study.
Exclusion criteria
Exclusion criteria: 1. Persons whose blood CRP exceeds 0.2 mg/dL within 1 month 2. Persons with positive serum anti-CCP antibody within 6 months 3. Persons with positive serum antinuclear antibody within 6 months 4. Persons who meet the criteria for classification of the following autoimmune diseases or have a history of such diseases (rheumatoid arthritis, systemic lupus erythematosus, systemic scleroderma, Sjogren's syndrome, idiopathic inflammatory muscle disease, ankylosing spondylitis, psoriatic arthritis) 5. Persons who have skin diseases at the site of wearing the warmer 6. Persons with peripheral neuropathy of upper extremities or past medical history of that (e.g., cervical spondylosis, diabetic neuropathy, carpal tunnel syndrome, etc.) 7. Persons unable to remove/wear the warmers by themselves 8. Persons who are judged ineligible by the investigators for other reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The change in the average Morning stiffness severity recorded in the participants' diary between the warmer-applied period and non-warmer-applied period. MS severity is defined the 0-10 numerical scale for the intensity of morning stiffness on his/her hands assessed by a participant himself/herself. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.Visual Analogue Scale (VAS: 0-100 mm) for hand joint pain during the day 2. VAS for degree of disturbance by menopausal hand symptoms to daytime work 3. grip strength on waking 4. evaluation of upper limb function by questionnaire (HAND20) 5. adverse events | — |
Contacts
Public ContactAkane Watanabe
The University of Osaka Hospital
Outcome results
None listed