Prostate cancer Prostate cancer, Robot-assisted laparoscopic radical prostatectomy, intravenous lidocaine
Conditions
Interventions
1) Administration of lidocaine or saline solution
During the induction of anaesthesia, an initial dose equivalent to 1.5 mg/kg is administered over 10 minutes, followed by continuous administration
Sponsors
Matsuura Hideki
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1) Male patients undergoing scheduled robotic-assisted laparoscopic total prostatectomy 2) Patients with American Society of Anaesthesiologists physical status classification1-3 3) Age between 20 and 85 years 4) Patients with written consent to participate in the study
Exclusion criteria
Exclusion criteria: 1) Patients who are scheduled to undergo urgent surgery 2) Patients who are being treated with beta-blockers (oral intake or patch) 3) Patients taking steroids 4) Patients taking cimetidine 5) Patients with a history of hypersensitivity to lidocaine 6) Patients with severe conduction system disorders 7) Patients with severe liver disorders (Child B or C) 8) Patients with severe renal disorders (eGFR <30) 9) Patients who are unable to secure the measurement site, e.g. after finger amputation or with nail lesions 10) Patients who are incapable of consenting 11) Patients who are judged to be inappropriate as research subjects by the (co-)investigators responsible for the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NRS (Numerical Rating Scale) values during body movements at 2 hours postoperatively | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Changes in biomarker values: IL-6 (after anesthesia induction, at the end of surgery, postoperative day 1) CRP (at anesthesia outpatient visit, postoperative day 1, postoperative day 3) Cortisol (after anesthesia induction, at the end of surgery) 2) Total amount of remifentanil used during surgery 3) Changes in QoR-15 scores on the day before surgery and postoperative days 1 and 2 4) Pain scores (NRS values) at rest preoperatively, 2 hours after surgery, and on postoperative days 1, 2, 3, 7, and 3 months 5) Perioperative consumption of narcotics (opioids) and analgesics 6) Presence or absence of prolonged postoperative pain at 3 months | — |
Contacts
Public ContactHideki Matsuura
Nara Medical University Hospital
Outcome results
None listed