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MSSP RCT

Randomized controlled trial comparing root canal filling using resin sealer without gutta-percha point to using conventional technique of root canal filling. - MSSP RCT

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
JPRN
Registry ID
JPRN-jRCTs052240103
Enrollment
384
Registered
2024-08-01
Start date
2024-08-01
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

irreversible pulpitis pulp necrosis Apical periodontitis Irreversible pulpitis, Pulp necrosis, Apical periodontitis

Interventions

group configuration

Sponsors

Takahashi Yusuke
Lead Sponsor
Hayashi Mikako
Collaborator

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: (1) Diagnosis of irreversible pulpitis, pulp necrosis, or apical periodontitis based on pulp and periodontal histology and imaging (dental radiographs and dental cone-beam CT). (2) It has been determined that healing is possible by root canal treatment using the standard method. (3) The patient is between 18 and 90 years of age at the time of consent and is capable of consenting. (4) The patient's condition is expected to be stable for at least 12 months from the time consent is obtained. (5) Written consent to participate in this study has been obtained from the patient.

Exclusion criteria

Exclusion criteria: (1) Has an allergy to raw materials used for root canal filling sealer. (2) With horizontal or vertical root fracture. (3) Perforation difficult to repair and removal of foreign body in root canal difficult to remove. (4) Traffic between periodontal pocket and root canal lesion. (5) History of root tip resection and intentional replantation. (6) It is judged that normal root canal treatment is extremely difficult due to morphological reasons of the root canal, such as dens invaginatus. (7) Patient has a deciduous tooth and a stenotic root canal, and the final magnification of root canal formation is #35 or less. (8) Diagnosed with diabetes mellitus. (9) Patients who are judged to be inappropriate as research subjects by the principal investigator or a sub investigator for other reasons.

Design outcomes

Primary

MeasureTime frame
Evaluation of periodontal tissue at the root apex using CBCT and clinical symptoms

Secondary

MeasureTime frame
(1) Evaluation of treatment time (2) Evaluation of periodontal tissue at the root apex using dental radiographs (3) Obtaining VAS values (4) Evaluation of periodontal pockets (5) Horizontal percussion pain (6) Degree of mobility (7) Condition of gingiva corresponding to root apex

Contacts

Public ContactYusuke Takahashi

Osaka University Dental Hospital

takahashi.yusuke.dent@osaka-u.ac.jp+81-6-6879-2927

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026