Healthy subjects
Conditions
Interventions
Five tests will be conducted on the study participants: a sitting test, a standing test, a low-intensity lower-limbs artificial negative pressure (LANP) test, a moderate-intensity LANP test, and a hig
Sponsors
Sakai Yoshitada
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Individuals who have provided consent. 2) Healthy subjects aged 18 years or older but less than 40 years at the time of obtaining consent. 3) Individuals with normal resting blood pressure (systolic blood pressure 100 to 139 mmHg and diastolic blood pressure 60 to 89 mmHg). 4) Normal weight individuals (BMI 18.5 to 24.9).
Exclusion criteria
Exclusion criteria: 1) Individuals who have experienced orthostatic hypotension accompanied by symptoms such as dizziness or nausea in the past 6 months. 2) Individuals with tachyarrhythmic or bradyarrhythmic arrhythmias. 3) Individuals taking cardiovascular medications that affect blood pressure, heart rate, or autonomic nervous activity (antihypertensive drugs, antiarrhythmic drugs, heart failure treatment drugs, etc.). 4) Women who are pregnant, may be pregnant, or are breastfeeding. 5) Others deemed inappropriate for the study by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Presence or absence of adverse events Presence or absence of malfunctions in the test equipment | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in cardiovascular parameters from rest during LANP loading and gravitational loading | — |
Contacts
Public ContactTakumi Hirabayashi
Kobe University Hospital
Outcome results
None listed