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Safety Evaluation of Hippocampal Stimulation Targeting Sharp Wave Ripple

Safety Evaluation of Hippocampal Stimulation Targeting Sharp Wave Ripple

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-jRCTs052230082
Enrollment
4
Registered
2023-08-01
Start date
2025-11-08
Completion date
Unknown
Last updated
2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

epilepsy epilepsy

Interventions

(1) Synchronous stimulation After the implantation of intracranial electrodes, SWR is detected from the intracranial electrodes implanted around the hippocampus, and electrical stimulation is performe

Sponsors

Yanagisawa Takufumi
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Primary Registration (1) Patients who have had electrodes implanted around the hippocampus during preoperative examinations for epilepsy. (2) Patients who are between 18 and 80 years of age at the time of consent. (3) Patients who have given written consent to participate in this study from themselves or their representative. Secondary enrollment (4) Those with a correct response rate of 60% or higher on up to 60 Sternberg working memory tasks with a load of 3 or higher.

Exclusion criteria

Exclusion criteria: Primary Registration (1) Patients who are considered incapable of performing the task due to severe higher-order functional disabilities. (2) Patients who are judged by the principal investigator or sub-investigator to be inappropriate as research subjects for other reasons. Secondary registration Not particularly.

Design outcomes

Primary

MeasureTime frame
Adverse events caused by electrical stimulation around the hippocampus after intracranial electrode implantation (includes only epileptic seizures with after discharge immediately after stimulation)

Secondary

MeasureTime frame
(1) Correct response rate and reaction time of Sternberg's working memory task under electrical stimulation of electrodes around the hippocampus after intracranial electrode implantation (2) Frequency of SWR around the hippocampus for each task

Contacts

Public ContactTakufumi Yanagisawa

The University of Osaka Hospital

tyanagisawa@nsurg.med.osaka-u.ac.jp+81-6-6879-3652

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Sep 19, 2026