Major depressive disorder
Conditions
Interventions
Electrodes are placed over the dorsolateral prefrontal cortex (DLPFC) using DC stimulator MR (neuroCOnn Gmbh). In a total of 20 daily sessions that lasted 20 minutes per day, 2 mA of direct current st
Sponsors
Habata Kaie
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The inclusion criteria are as follows: 1) Inpatients in the department of psychiatry of the University of Fukui Hospital 2) Male or female patients between 25 and 90 years of age 3) Diagnosed major depressive disorder according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5; American Psychiatric Association) 4) Moderate to severe depressive state according to the Hamilton Depression Rating Scale (score <= 17) 5) Patients provides written informed consent prior to initiation of any study procedures
Exclusion criteria
Exclusion criteria: Exclusion criteria 1) Past or current diagnosis of schizophrenia, schizoaffective disorder, bipolar I disorder and bipolar II disorder 2) Presence of severe physical diseases or in the terminal phase of the disease 3) Under treatment for thyroid function abnormality 4) With abnormal EEG findings 5) With intracranial space-occupying lesion 6) pregnancy 7) Need to be cured urgently due to severe depressive state with inability take any food and/or severe suicidal ideation 8) Lack of cooperation regarding 20-minutes procedure of tDCS due to severe agitation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1) The primary efficacy outcomes are the changes from baseline in symptom rationg scale, including Hamilton Depression Rating Scale (HAMD-17), the Mental and Physical Ques tionnaire (PHQ), and the Beck Depression Questionnaire, Second Edition (BDI-II) 2) Safety is evaluated by evaluated by Proposal of a questionnaire surveying for tDCS adverse effects (PQSTAE) | — |
Contacts
Public ContactHabata Kaie
University of Fukui Hospital
Outcome results
None listed