Central Nervous System Diseases neurological disorders
Conditions
Interventions
Forty patients will be randomly divided into two groups in each disability function of neurological disease patients, and assigned 20 patients in the "noninvasive brain stimulation and rehabilitation
tDCS, rehabilitation
Sponsors
Hanakawa Takashi
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients) 1 Patients who are 18years of ag e or older at the time of consent to participate in th e study and are undergoing medical treatment at th e outpatient department of neurology or inpatient d epartment of Kyoto Ohara Memorial Hospital, Kyoto Konoe Rehabilitation Hospital, Gosyo Minami Rehab ilitation Clinic, or Kyoto University Hospital. 2 Patients who have developed cerebrovascular disorders, neuromuscular degenerative diseases, involuntary movement diseases, neuromuscular inflammatory diseases, central neurological disorders, or traumatic central neurological disorders, post-delirium and psychiatric-related cognitive impairment and for whom the diagnosis has been established by neurological findings, imaging findings 3 6 days or more after the onset of symptoms, or 6 days or more after the recurrence of symptoms 4 Patients suffering from any of the following disorders due to neurological diseases: motor disorder, higher brain dysfunction, language disorder, and dysphagia 5 Patients who have given a full explanation and have given written consen from the person or proxy if written consent from the person is difficult to obtain Healthy volunteers) (i) 18 to 90 years old at the time of consent (ii) Have no history of neurological or psychiatric disorders (iii) After receiving a full explanation of the purpose of participation in this study, the subject must give his/her free and voluntary written consent based on full understanding, or if the subject is unable to give his/her written consent, a proxy must give his/her written consent.
Exclusion criteria
Exclusion criteria: Patients) 1 5 days or more before the onset of symptoms, or 5 days or more before the recurrence of symptoms 2 Patients who are difficult to communicate due to significant hearing impairment 3 Patients who has metals in the body which cannot be confirmed to be non-magnetic *In the case of deep brain stimulating electrodes, however, since it has been reported that transcranial direct current stimulation is safe and effective when deep brain stimulation is stopped even when the electrode is intracranial, participation is possible when the deep brain stimulating electrode is intracranial but the stimulation is turned off. 4 Those who are judged inappropriate as a participant by the "Transcranial Magnetic Stimulation Test / Pre-Checklist" and "MR Test Pre-Checklist". 5 Those who are with claustrophobia 6 Any other person who is judged by the principal investigator to be inappropriate as a research subject Healthy volunteers) 1 If he/she has a metal (aneurysm clips, mechanical prosthetic valves, nerve stimulators, insulin pumps, intraocular metal, etc.) in his/her body that cannot be confirmed to be non-magnetic. 2 In case of non compliance with the "Transcranial Magnetic Stimulation Test / Pre-Checklist" and "MR Test Pre-Checklist". 3 If the subject has claustrophobia 4 Other cases in which the principal investigator determines that the subject is inappropriate as a research subject.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Activity changes in EEG (analysis of EEG amplitude, frequency analysis) | — |
Secondary
| Measure | Time frame |
|---|---|
| Amplitude values in each frequency band of MEG Changes in cerebral blood flow during the task and at rest by fMRI Motor evoked potential by TMS Evaluation of motor and cognitive functions Evaluation of neuroplasticity-related factors (BDNF, myokines) Physical activities Nutrition quantity | — |
Contacts
Public ContactTomoya Gyoda
Kyoto university
Outcome results
None listed