Comparison of GI tract pH and motility between patients with ulcerative colitis and healthy controls

Comparison of total gastrointestinal pH and motility between healthy subjects and patients with ulcerative colitis using wireless motility/pH capsule

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCTs052210199

Enrollment

Registered

2022-03-22

Start date

2022-03-22

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ulcerative colitis

Interventions

arm UC arm Health control In each case, the SmartPill motility capsule is orally taken with 50 ml of water. The temperature, pH and pressure of the entire digestive tract are measured in real time. A

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Selection criteria common to UC patients and healthy controls (1) 20 years old and over, 79 years old or under (2) Person who can obtain consent by document 2. Selection criteria for UC patients (1) Patients diagnosed with left-sided colitis-type or total colitis type UC (10 active and 10 remission) (2) Treatment content for UC does not matter Active phase was defined as a SCCAI >=3 and remission was defined as a SCCAI <=2

Exclusion criteria

Exclusion criteria: 1. Exclusion Criteria Common to UC Patients and Healthy controls (1) A person with a history of intestinal surgery (excluding appendectomy) (2)Those who have a history of bowel obstruction (3) Those with intestinal stricture (4) Persons whose defecation interval exceeds 48 hours on average (5) Patients who have difficulty swallowing (6)Those who have taken drugs that affect intestinal motility (antidiarrheal, laxatives, intestinal motility enhancers, etc.) within 7 days of the start of the test. (7)Those who have taken drugs (H2 receptor antagonists, proton pump inhibitors, etc.) that affect gastric acid secretion within 7 days of the start of the test (8) Those who are pregnant or may be pregnant (9)Those who have judged that it is inappropriate by the investigator to participate in this study (10) Those with pacemakers

Design outcomes

Primary

Measure	Time frame
Comparison between arm UC and arm Health control in the following items 1 Stomach pH 2 Small intestinal pH 3 Large intestine pH 4 Gastric emptying time (GET) 5 small bowel transit time (SBTT) 6 Colonic traisit time (CTT)	—

Secondary

Measure	Time frame
Comparison between arm UC and arm Health control in the following items 1 Stomach pH 2 Small intestinal pH 3 Large intestine pH 4Gastric emptying time (GET) 5 Small bowel transit time (SBTT) 6 Colonic traisit time (CTT) 7 Sites that exceed pH7 for the first time [stomach, small intestine (proximal part), small intestine (middle part), small intestine (distal part), large intestine]	—

Contacts

Public ContactTakako Miyazaki

Osaka Medical and Pharmaceutical University

takako.miyazaki@ompu.ac.jp+81-72-683-1221

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026