Leber Hereditary Optic Neuropathy
Conditions
Interventions
skin electrical stimulation
Sponsors
Nakamura Makoto
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Age:>=16years, =0.01, <0.1
Exclusion criteria
Exclusion criteria: (1) Best corrected decimal visual acuity <0.01 (2) A history if smoking within 1 year (3) A history of the implantation of electronic devices such as cardiac pacemakers etc. (4) A history of inraocular surgery within the past 1 year. (5) A history of other eye diseases. (6) Idebenone treatment within 1 year (7) Treatment with Ethanbutol, chloramphenicol, linezolid, erythromycin, streptomycin, anti-retrovirus drug, amiodarone, infliximab, clioquinol etc. (8) A history of epilepsy (9) pregnancy (10) Severe allergic diseases including atopic dermatitis (11) Participating in other clinical studies
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement rate of LogMAR visual acuity 1 week after final skin electrical stimulation compared to LogMAR visual acuity before electrical skin stimulation | — |
Secondary
| Measure | Time frame |
|---|---|
| (1) Time course of LogMAR visual acuity after electrical skin stimulation (2) Time course of visual field after electrical skin stimulation (3) Time course of Critical Flicker Frequency after electrical skin stimulation (4) Time course of papillocircum retinal nerve fiber thickness and macular retinal ganglion cell complex thickness by optical coherence tomography after electrical skin stimulation (5) Corneal endothelial cell density before and after electrical skin stimulation (6) Safety during electrical skin stimulation | — |
Contacts
Public ContactYuko Nakanishi
Kobe University Hospital
Outcome results
None listed