Denervation of autonomic plexus around pulmonary artery in pulmonary hypertension

Safety and Efficacy in denervation of autonomic plexus around pulmonary artery in patients with refractory pulmonary hypertension

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCTs052200017

Enrollment

Registered

2020-06-01

Start date

2020-10-19

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pulmonary hypertension

Interventions

Denervation of autonomic plexus around pulmonary artery using the Ablation catheter for arrhythmia

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Aged >= 16, Aged = 25 mmHg 3) Maximumal internal medications 4) NYHA functional class >= III 5) Provision of written consent

Exclusion criteria

Exclusion criteria: 1) Shocked patients with systolic BP 2hrs

Design outcomes

Primary

Measure	Time frame
Time to death from any cause, lung transplantation and clinical worsening (hospitalization for heart failure, >15% decrease in 6MWD from baseline, worsening WHO-FC, or need for additional PAH therapy)	—

Secondary

Measure	Time frame
1) Time to death from any cause 2) Time to lung transplantation 3) Time to clinical worsening (hospitalization of heart failure, >15% decrease in 6MWD from baseline, worsening WHO-FC, or need for additional PAH therapy)	—

Contacts

Public ContactRyotaro Asano

National Cerebral and Cardiovascular Center

asano201@ncvc.go.jp+81-6-6170-1070

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026