Alzheimers disease Alzheimers disease
Conditions
Interventions
Sponsors
Saitoh Youichi
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Diagnosis criteria from NINCDSADRDA Work Group: probable AD 2. MMSE: less than or equal to 25 3. CDR-J:1 or 2 4.The cognitive function control is insufficient though received medical therapy more than 6 months, or received medical therapy more than 6 months in the past 5.Age of the acquired the agreement: 20 years old or older 6.Written informed consents or informed assent, which the person and proxies such as families as well as a patient acquired the agreement, are obtained
Exclusion criteria
Exclusion criteria: 1.Severe dementia MMSE: less than or equal to 9 2.Severe psychiatric disorder 3.Past medical history epilepsy 4.drug abuse or dependence, including alcoholism 5.with a desire for suicide 6.Pregnant and Wishing to get Pregnant 7.having heart pacemaker or drug infusion pomp 8.having the deep brain stimulation or the spinal cord stimulation 9.with an implanted metal, except for titanium products, in their heads 10.considered unsuitable for this clinical trial by a principal or sub investigator 11.Judged as inappropriate for this study by doctors
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Amount of change from the value after the last intervention to the pre-intervention | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.MMSE The changing rate after the last intervention relative to the pre-intervention The percentage of the number of subjects who improved the value immediately after the last intervention with respect to the pre-intervention value by 3 points or more 2.ADAS-cog The changing value and changing rate after the last intervention relative to the pre-intervention The percentage of the number of subjects who improved the value immediately after the last intervention with respect to the pre-intervention value by 3 points or more 3.MoCA-J The changing value and changing rate after the last intervention relative to the pre-intervention 4.CDR-J The changing value of SUM OF BOXES after the last intervention relative to the pre-intervention The percentage of the number of subjects who improved the value immediately after the last intervention with respect to the pre-intervention value by 1 points or more 5.NPI The changing value after the last intervention relative to the pre-intervention 6.EQ-5D-5L The changing value and changing rate after the last intervention relative to the pre-intervention 7.CGIC The number and percentage of 1, 2 or 3 after the intervention 8.MMSE memory items Immediate Recall, Delayed Reproduction and Repeat The changing value and changing rate after the last intervention relative to the pre-intervention The percentage of the number of subjects who improved the value immediately after the last intervention with respect to the pre-intervention value by 2 points or more 9.electroencephalography The changing value the ratio of alpha wave and beta wave, after intervention to the pre-intervention 10.adverse effects diagnosis name, onset time of illness , disappearance time, frequency, disease severity, the causation, an outcome and severity | — |
Contacts
Public ContactYouichi Saitoh
Osaka University Hospital
Outcome results
None listed